Advanced Cardiovascular Life Support (ACLS) Practice Exam 2025 - Free ACLS Practice Questions and Study Guide

The recommended duration of therapeutic hypothermia after reaching the target temperature is typically between 12 to 24 hours. This timeframe is based on clinical guidelines that suggest maintaining mild hypothermia (usually in the range of 32 to 34 degrees Celsius) for this duration to optimize neuroprotection following events like cardiac arrest. Research indicates that this period is associated with improved outcomes for survival and neurological function.

Continuing therapeutic hypothermia for 12 to 24 hours allows for the reduction of metabolic demands and may help mitigate neurological injury by slowing down cellular processes that can contribute to damage. The choice of duration is critical, as extending beyond this period may not confer additional benefits and could pose risks, such as complications related to prolonged cooling.

While options beyond this duration, such as 36 to 48 hours, may seem attractive for maximizing protective effects, current evidence and standards favor the 12 to 24-hour window as optimal.